人肺腺癌细胞LC-2

细胞名称

人肺腺癌细胞LC-2

货物编码

BFN681363

产品规格

T25培养瓶x1

1.5ml冻存管x2

细胞数量

1x10^6

1x10^6

保存温度

37℃

-198℃

运输方式

常温保温运输

干冰运输

安全等级

1

用途限制

仅供科研   2类

培养体系

DMEM高糖（HYCLONE SH30022.01)+10%FBS+1%三抗

培养温度

37℃

二氧化碳浓度

5%

简介

人肺腺癌细胞LC-2取自51岁女性供体。

注释

Part of: Cancer Cell Line Encyclopedia (CCLE) project.

Part of: COSMIC cell lines project.

Population: Japanese.

Doubling time: 58 hours, at 32th passage (PubMed=8291444).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Deep exome analysis.

Omics: DNA methylation analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis.

基因突变

Gene fusion CCDC6-RET (RET/PTC1) (PubMed=23578175).

EGFR p.Leu858Arg (c.2573T>G) (ClinVar=VCV000016609) (PubMed=16105816).

EGFR p.Glu746_Ala750del (PubMed=23154560).

Homozygous for TP53 p.Ser241Cys (c.722C>G) (ClinVar=VCV000177791) (Cosmic-CLP).

HLA信息

/

STR信息

Amelogenin X

CSF1PO 10,11

D5S818 10

D7S820 11

D13S317 10,12

D16S539 9

TH01 7

TPOX 11

vWA 16,19

参考文献

PubMed=23578175; DOI=10.1111/cas.12175

 Suzuki M., Makinoshima H., Matsumoto S., Suzuki A., Mimaki S., Matsushima K., Yoh K., Goto K., Suzuki Y., Ishii G., Ochiai A., Tsuta K., Shibata T., Kohno T., Esumi H., Tsuchihara K.

 Identification of a lung adenocarcinoma cell line with CCDC6-RET fusion gene and the effect of RET inhibitors in vitro and in vivo.

 Cancer Sci. 104:896-903(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017

 Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

 A landscape of pharmacogenomic interactions in cancer.

 Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747

 Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.

 An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

 Cancer Res. 79:1263-1273(2019)