人肾癌细胞RCC4

细胞名称

人肾癌细胞RCC4

货物编码

BFN60808420

产品规格

T25培养瓶x1

1.5ml冻存管x2

细胞数量

1x10^6

1x10^6

保存温度

37℃

-198℃

运输方式

常温保温运输

干冰运输

安全等级

1

用途限制

仅供科研        2类

培养体系

DMEM高糖+10%FBS+1%三抗

培养温度

37℃

二氧化碳浓度

5%

简介

人肾癌细胞RCC4取自女性供体，贴壁培养，不规则形态。

注释

Part of: Cancer Cell Line Encyclopedia (CCLE) project.

基因突变

Hemizygous for VHL p.Ser65Trp (c.194C>G) (PubMed=21258414).

HLA信息

/

STR信息

/

参考文献

PubMed=10353251; DOI=10.1038/20459

Maxwell P.H., Wiesener M.S., Chang G.-W., Clifford S.C., Vaux E.C., Cockman M.E., Wykoff C.C., Pugh C.W., Maher E.R., Ratcliffe P.J.

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.

Nature 399:271-275(1999)

PubMed=21258414; DOI=10.1038/onc.2010.638

Perier A., Fregni G., Wittnebel S., Gad S., Allard M., Gervois N., Escudier B., Azzarone B., Caignard A.

Mutations of the von Hippel-Lindau gene confer increased susceptibility to natural killer cells of clear-cell renal cell carcinoma.

Oncogene 30:2622-2632(2011)

PubMed=22949125; DOI=10.1002/ijc.27822

Pawlowski R., Muhl S.M., Sulser T., Krek W., Moch H., Schraml P.

Loss of PBRM1 expression is associated with renal cell carcinoma progression.

Int. J. Cancer 132:E11-E17(2013)

PubMed=27993170; DOI=10.1186/s12943-016-0565-8

Brodaczewska K.K., Szczylik C., Fiedorowicz M., Porta C., Czarnecka A.M.

Choosing the right cell line for renal cell cancer research.

Mol. Cancer 15:83-83(2016)

PubMed=28489074; DOI=10.1038/ncomms15165

Sinha R., Winer A.G., Chevinsky M., Jakubowski C., Chen Y.-B., Dong Y., Tickoo S.K., Reuter V.E., Russo P., Coleman J.A., Sander C., Hsieh J.J., Hakimi A.A.

Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.

Nat. Commun. 8:15165-15165(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747

Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3

Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Nature 569:503-508(2019)